The aim of present investigation was to compare the ionotropic gelation techniques for entrapping Aceclofenac in mucoadhesive microparticulate system. Aceclofenac microcapsules with a coat consisting of alginate and a mucoadhesive polymer sodium carboxymethylcellulose, methyl cellulose, carbopol and hydroxypropylmethylcellulose were prepared by two methods namely orifice-ionic gelation process and emulsification ionic gelation process. The resulting microcapsules were discrete, large, spherical and free flowing. Microencapsulation efficiency was in the range of 88.56-99.2% in case of Orifice ionic gelation method and 93.52-99.03% in case of emulsification method. The microcapsules exhibited good mucoadhesive property in the in vitro wash-off test. Aceclofenac release from these mucoadhesive microcapsules was slow and extended over longer periods of time depending on the composition of coat of the microcapsules. Drug release follows first order kinetics and non-Fickian type of diffusion. With all the mucoadhesive polymers, microcapsules prepared by Orifice method gave more slow release of the contained drug when compared to those prepared by Emulsification method. Alginate-sodium CMC and alginate-methyl cellulose microcapsules of Aceclofenac prepared by Orifice method sustained the drug release over a period of 20-24 h. These mucoadhesive microcapsules are thus, suitable for oral controlled release of Aceclofenac.
Loading....